Bottom of foot pain may occur if the sciatic nerve's S1 spinal nerve root is affected. Typical symptoms of pain in the bottom of the foot may include weakness in. May 14, - Morton's neuroma causes a thickening of the tissue around the nerves between the bases of the toes (usually between the third and fourth toes). You typically feel pain, odd sensations or numbness over the ball of your foot. Wear shoe inserts to reduce pressure on the nerve.Heel Pain · Ball of Foot Pain · Arch Pain · Toe Pain.